Women's Health Weekly
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Cancer Therapy
Inhibition of tumor-derived CCL5 also inhibited metastasis of 4T1
April 14th, 2005
Inhibition of tumor-derived CCL5 might inhibit the metastasis of 4T1 by modulating protease expression. "To determine whether tumor-derived CCL5 contributes to the metastatic potential of murine mammary carcinoma, we used the 4T1 tumor which spontaneously metastasizes and constitutively produces CCL5," said K.A. Stormes and colleagues of Lafayette College. The researchers concluded, "Mice bearing 4T1 that expressed less CCL5 had significantly fewer lung and liver metastasis. The decrease in tumor-derived CCL5 also correlated with decreased cathepsin L, MMP-2, MMP-3, MMP-10 and MMP-17 gene expression. Thus, inhibition of tumor-derived CCL5 can impact...
Source: Women's Health Weekly (2005-04-14)
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