Women's Health Weekly
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Cancer Therapy
The G-quadruplex-interactive molecule BRACO-19 inhibited tumor growth
April 14th, 2005
The G-quadruplex-interactive molecule BRACO-19 showcased its anticancer potential by inhibiting tumor growth. "Interference with telomerase and telomere maintenance is emerging as an attractive target for anticancer therapies. Ligand-induced stabilization of G-quadruplex formation by the telomeric DNA single-stranded 3' overhang inhibits telomerase from catalyzing telomeric DNA synthesis and from capping telomeric ends. We report here the effects of a 3,6,9-trisubstituted acridine compound, BRACO-19, on telomerase function in vitro and in vivo," scientists in England reported. A.M. Burger and colleagues from the University of London said, "The...
Source: Women's Health Weekly (2005-04-14)
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