Birth Defects
Nitrofen associated with birth defects
Published in Women's Health Weekly, April 21st, 2005
"Nitrofen is a diphenyl ether herbicide that produces a spectrum of fetal abnormalities in rodents. To characterize the molecular mechanisms of nitrofen-mediated birth defects at the cellular level, we explored its effects on undifferentiated P19 teratocarcinoma cells. Nitrofen induces a time-dependent cell death of P19 cells that is associated with increases in TUNEL-positivity and caspase-3 cleavage suggesting that nitrofen induces P19 cell apoptosis," scientists in the United States reported.
"In addition, the increase in TUNEL-positive cells was inhibited with zVAD-fmk,...
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