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Breast Cancer

Cytotoxic activity of ent-16 beta-17 alpha-dihydroxykaurane on breast cancer

"Here we describe the cytotoxic and proapoptotic effect of an ent-kaurane (ent-16beta-17alpha-dihydroxykaurane) compound isolated from Croton malambo, barks, on malignant cell growth," scientists writing in the journal Cancer Letters reported.

"When MCF-7 mammary carcinoma cells were treated with increasing concentrations of the ent-kauranoid, its cytotoxic activity showed an IC₅₀ of 12.5 mcg/ml, dose that is 2.66-fold lower than the corresponding value for non-malignant cells. At this growth inhibitory...

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