Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Breast Cancer
Inactive human cathepsin D triggered fibroblast invasive growth
April 21st, 2005
Inactive human cathepsin D (cath-D) was observed to trigger fibroblast invasive growth. "The aspartyl-protease cath-D is over-expressed and hypersecreted by epithelial breast cancer cells and stimulates their proliferation. As tumor epithelial-fibroblast cell interactions are important events in cancer progression, we investigated whether cath-D overexpression affects also fibroblast behavior. We demonstrate a requirement of cath-D for fibroblast invasive growth using a three-dimensional (3D) coculture assay with cancer cells secreting or not pro-cath-D," researchers in France reported. "Ectopic expression of cath-D in cath-D-deficient fibroblasts...
Source: Women's Health Weekly (2005-04-21)
|
