Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Breast Cancer
Polymorphisms in DNA repair gene XRCC1 may increase genetic susceptibility
April 21st, 2005
Polymorphisms in the DNA repair gene XRCC1 may increase genetic susceptibility to breast cancer, suggest results of a study of South Indian women. "X-ray repair cross-complementing 1 (XRCC1) gene encodes for a scaffolding protein, which plays an important role in base excision DNA repair by bringing together DNA polymerase beta, DNA ligase III, and poly(ADP-Ribose) polymerase (PARP) at the site of DNA damage. Three polymorphisms of the XRCC1 gene at codons 194, 280, and 399 leading to amino acid changes at evolutionary conserved regions are found to alter the efficiency of the resulting protein and may therefore constitute potential breast cancer risk," wrote Priya...
Source: Women's Health Weekly (2005-04-21)
|
