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Cancer Drugs
Novel cytotoxic cyclic peptide, YM-216391, derived from Streptomyces nobilis
April 21st, 2005
Researchers derived a novel cytotoxic cyclic peptide, YM-216391, from Streptomyces nobilis. According to a study from Japan, "YM-216391, a novel cyclic peptide, was isolated from the cultured mycelium of S. nobilis JCM 4274." "It was purified by solvent extraction, silica gel and ODS flash column chromatographies, followed by preparative HPLC," explained K.Y. Sohda and colleagues, Yamanouchi Pharmaceutical Co. Ltd. "YM-216391 also showed potent cytotoxic activity against a human cancer cell line panel," added the investigators. The researchers concluded, "YM-216391 dose-dependently inhibited the...
Source: Women's Health Weekly (2005-04-21)
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