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Women's Health Weekly

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Cervical Cancer



New findings in the area of cervical cancer detailed



April 28th, 2005

Data on cervical cancer are outlined in reports from France, Mexico and Australia.

Study 1: Human papillomavirus oncoprotein E7 targeted the promyelocytic leukemia protein and circumvented senescence via the Rb and p53 tumor suppressor pathways.

"Cellular senescence can be triggered by a variety of signals, including loss of telomeric integrity or intense oncogenic signaling, and is considered a potent, natural tumor suppressor mechanism. Previously, it was shown that the promyelocytic leukemia protein (PML) induces cellular senescence when overexpressed in primary human fibroblasts," researchers in France reported.

"The mechanism...


Source: Women's Health Weekly (2005-04-28)

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