Women's Health Weekly
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Breast Cancer
Environmental estrogens on [Ca2+]i in human breast cancer cells studied
April 28th, 2005
Scientists investigated the effects of environmental estrogens on intracellular calcium ion concentration ([Ca2+]i ) in human breast cancer cells. "The aim of this study was to identify and characterize an alternative pathway through which environmental estrogenic compounds may mediate their intracellular effects. Three human breast cancer cell lines were employed including MCF-7 cells, which express both ERalpha and ERbeta; MDA-MB-231 cells, which express ERbeta but not ERalpha; and SKBR-3 cells, which express neither ERalpha nor ERbeta. The effect of environmental estrogenic compounds on [Ca2+]i was measured and compared to...
Source: Women's Health Weekly (2005-04-28)
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