Women's Health Weekly
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Breast Cancer
PKC delta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer
April 28th, 2005
PKC delta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer cells. "The effects of activating endogenous protein kinase C (PKC) on cell proliferation and the cell cycle were investigated by treating the breast cancer cell line SKBR-3 with phorbol 12-myristate 13 acetate (PMA). This inhibited cell growth in a concentration-dependent manner, causing a marked arrest of cells in G(1). "Pretreatment with GF109203X completely blocked the antiproliferative effect of PMA, and pretreatment with the PKCdelta inhibitor rottlerin partially blocked it," scientists in Japan report. "Infecting SKBR-3 cells with an adenovirus...
Source: Women's Health Weekly (2005-04-28)
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