Women's Health Weekly
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Breast Cancer Research
Copper and zinc induced apoptosis in breast cancer cells
April 28th, 2005
Scientists suggested copper and zinc induce apoptosis in breast cancer cells. According to a study from Canada, "Previous studies revealed that cells may differ in their response to metal stress depending on their p53 status; however, the sequence of events leading to copper-induced apoptosis is still unclear. Exposure of copper (10 and 25 mcM) and zinc (10 and 25 mcM) caused activation of p53 in ER+/p53+ human epithelial breast cancer MCF7 cells and resulted in upregulation of p21." "Transactivation of p53 in MCF7 cells also led to increase in expression of Bax, proapototic Bcl-2 family member, triggering mitochondrial pore opening, and PIG3...
Source: Women's Health Weekly (2005-04-28)
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