Women's Health Weekly
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Breast Cancer Vaccine
Structural consequences of increasing repeats in MUC1 tumor antigen reported
April 28th, 2005
Researchers report the structural and dynamic consequences of increasing repeats in a MUC1 peptide tumor antigen in a recent issue of Biopolymers. According to published research from the United States, "MUC1 mucin is a large transmembrane glycoprotein whose extracelluler domain is composed of repeating units of a 20-amino-acid sequence. In the cancer associated state, this protein expression becomes upregulated and underglycosylated. Previous studies, which show an enhanced binding of a 5-repeat over a 1-repeat MUC1 peptide to a panel of anti-MUC1 antibodies, have led us to investigate the structural and dynamic consequences of increasing repeat number." ...
Source: Women's Health Weekly (2005-04-28)
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