Women's Health Weekly
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Cancer Drugs
Effect of novel spirohydantoin derivatives on cancer cells evaluated
April 28th, 2005
Scientists evaluated the effect of novel spirohydantoin derivatives on cancer cells. "The synthesis and cytotoxic evaluation of 3-(alkyl)(alkyl-substituted)spiro[(dihydroimidazo-2,4-dione)-5,3'-(2',3'-dihydrothieno[2,3-b]naphtho-4',9'-dione)] derivatives are described. Evaluation of these analogues against the MCF-7 human breast carcinoma and SW 620 human colon carcinoma cell lines uncovered for most of the compounds a cytotoxic potency comparable to or greater than that of doxorubicin. Compound 15 exhibited remarkable cytotoxic activity against several other human solid tumor cell lines," investigators in Italy reported. "Interestingly, only a...
Source: Women's Health Weekly (2005-04-28)
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