Cervical Cancer

Loss of Net as repressor led to increased c-fos transcription in cervical cancer

Published in Women's Health Weekly, April 28th, 2005

Researchers found that the loss of Net as a repressor might lead to increased c-fos transcription in cervical cancer cells.

"We have investigated the expression of c-fos in cervical carcinoma cells and in somatic cell hybrids derived therefrom. In malignant cells, c-fos was constitutively expressed even after serum starvation. Dissection of the c-fos promoter showed that expression was mainly controlled by the SRE motif, which was active in malignant cells, but repressed in their nonmalignant counterparts," scientists in Germany reported.

"Constitutive SRE activity was not mediated by sustained mitogen-activated protein kinase activity but because of...

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Source: Women's Health Weekly (2005-04-28)

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