Women's Health Weekly
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Birth Defects
Maternal polymorphisms in CYP1A1, GSTM1, and GSTT1 linked to risk of hypospadias
May 5th, 2005
Maternal genetic polymorphisms in CYP1A1, GSTM1, and GSTT1 linked to the risk of hypospadias. According to a study from Japan, "Hypospadias is one of the most common congenital anomalies. Increased exposure to environmental factors (endocrine-disrupting chemicals and smoking) or maternal endogenous estrogen may cause hypospadias because male sexual differentiation is dependent on normal androgen homeostasis. Moreover, interactions between genetic factors and cigarette smoking and other chemicals have been suggested." "It has been demonstrated that the CYP1A1 metabolizes not only environmental chemicals but also estrogens, and...
Source: Women's Health Weekly (2005-05-05)
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