Women's Health Weekly
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Breast Cancer
Effects of estrogen and tamoxifen on tumor gene expression characterized
May 5th, 2005
The effects of estrogen and tamoxifen on breast tumor gene expression have been further characterized. "To explore the mechanisms whereby estrogen and antiestrogen (tamoxifen (TAM)) can regulate breast cancer cell growth," endocrinologists in France "investigated gene expression changes in MCF7 cells treated with 17beta-estradiol (E2 ) and/or with 4-OH-TAM." "The patterns of differential expression were determined by the ValiGen Gene IDentification (VGID) process, a subtractive hybridization approach combined with microarray validation screening," explained F. Gadal and coauthors at Hopital Saint-Louis in Paris. "Their possible biologic...
Source: Women's Health Weekly (2005-05-05)
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