Women's Health Weekly
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Breast Cancer
PEA3 and AP-1 involved in regulation of breast cancer-linked gene, mammaglobin
May 5th, 2005
PEA3, AP-1, and a unique repetitive sequence have been implicated in the regulation of the breast cancer-associated gene, mammaglobin. "The breast cancer-associated gene mammaglobin is a member of the secretoglobin protein family and has demonstrated its utility as a breast cancer marker. However, the transcriptional regulation of mammaglobin has not been well characterized. In this report, we used luciferase reporter assays to identify the 200 bp directly 5' of the transcriptional start site as the minimal promoter region of mammaglobin," scientists in the United States reported. "Sequence scanning indicated that two PEA3 transcription sites were...
Source: Women's Health Weekly (2005-05-05)
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