Women's Health Weekly
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Cervical Cancer
p27(Kip1) downregulated telomerase activity in human cervical cancer
May 5th, 2005
Interferon-gamma (IFN-gamma)/IRF-1-induced p27(Kip1) might downregulate telomerase activity and human telomerase reverse transcriptase (hTERT) expression in cervical cancer. "Telomerase activation is regulated by the expression of hTERT and is a key step in the development of human cancers. IFN-gamma signaling induces growth arrest in many tumors through multiple regulatory mechanisms. The p27 tumor suppressor protein inhibits the formation of tumors through the induction of cell cycle arrest and/or apoptosis," researchers in South Korea reported. "We demonstrate here that p27(Kip1) inhibits hTERT mRNA expression and telomerase activity through...
Source: Women's Health Weekly (2005-05-05)
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