Women's Health Weekly
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Colorectal Cancer
Tumor formation and intestinal cell migration prevented by estrogens
May 5th, 2005
According to recent research from the United States, "Epidemiological studies suggest that postmenopausal hormone replacement therapy (HRT) reduces colorectal cancer (CRC) incidence. "Phytestrogens, including the soy isoflavone genistein and coumestrol, are used by many women as alternatives to HRT. Previous studies showed that ovariectomy induced a 77% increase in intestinal adenoma number in the C57BL/6J-Min/+ (Min/+) mouse, an animal model of adenomatous polyposis coli (APC)-associated CRC. Replacement of estradiol (E-2) in ovariectomized Min/+ mice reduced tumor number to baseline and upregulated the expression of estrogen receptor beta (ERbeta)." ...
Source: Women's Health Weekly (2005-05-05)
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