Women's Health Weekly
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Breast Cancer
2-methoxyestradiol downregulated cyclin D1 and cell cycle progression
May 12th, 2005
2-Methoxyestradiol (2-ME2) was suggested to downregulate cyclin D1 and cell cycle progression. "We studied the effects of 2-ME2 and 16alpha-hydroxyestrone (16alpha-OHE1), two metabolites of estradiol (E-2) on DNA synthesis, cell cycle progression and cyclin D1 protein levels in estrogen receptor-positive MCF-7 cells. E-2 and 16alpha-OHE1, stimulated DNA synthesis, and 2-ME2 inhibited the stimulatory effects of these agents. E-2 and 16alpha-OHE1, stimulated the progression of cells from G1 to S phase and this effect was attenuated by 2-ME2," scientists reported in the Journal of Molecular Endocrinology. "Western blot analysis showed...
Source: Women's Health Weekly (2005-05-12)
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