Women's Health Weekly
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Breast Cancer
Beta 2-chimerin induced murine breast cancer cells to respond to matrix stimuli
May 12th, 2005
Scientists suggested beta 2-chimerin might induce murine breast cancer cells to respond when stimulated by the extracellular matrix. According to a study from Argentina, "Chimerins are high affinity receptors for phorbol esters and diacylglycerol (DAG), unrelated to the protein kinase C isozymes. These receptors have deep implications in tumor biology since they regulate the activity of Rac1, a small GTP-binding protein of the Ras superfamily. It has been demonstrated that chimerins have GTPase activating protein (GAP) activity, leading to the acceleration of GTP hydrolysis from Rac1 and therefore facilitating the transition to its inactive state." ...
Source: Women's Health Weekly (2005-05-12)
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