Women's Health Weekly
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Breast Cancer
Reducing gene expression improves cancer cells' response to ionizing radiation
May 12th, 2005
Reducing expression of a gene called BRCC36 that interacts with the breast cancer susceptibility gene 1 (BRCA1) makes breast cancer cells more responsive to ionizing radiation, according to scientists at Fox Chase Cancer Center in Philadelphia. BRCC36 directly interacts with the BRCA1 protein. Almost all invasive breast cancer cells have elevated BRCC36 levels compared to normal breast milk-duct cells. "Since BRCC36 directly affects BRCA1 and BRCA1 is activated after exposure to radiation, we wanted to see if BRCC36 might be important in this response," said Xiaowei Chen, PhD, a Fox Chase postdoctoral researcher in the laboratory of geneticist Andrew...
Source: Women's Health Weekly (2005-05-12)
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