Women's Health Weekly
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Breast Cancer
Transcriptional regulation of LRP16 gene expression in MCF-7 human breast cancer
May 12th, 2005
Researchers suggested that LRP16 gene expression could be transcriptionally regulated in MCF-7 human breast cancer. "LRP16 gene expression is induced by 17-beta estradiol (E2) via estrogen receptor alpha (ERalpha) in MCF-7 human breast cancer cells. A previous study also demonstrated that ectopic expression of LRP16 gene promoted MCF-7 cell proliferation. To explore the mechanism of hormone-induced LRP16 gene expression, the LRP16 gene promoter region (-2600 to -24 bp upstream of the LRP16 gene translation starting site) was analyzed in the present study by using different 5'-truncated constructs, and a luciferase reporter," scientists from the People's Republic of...
Source: Women's Health Weekly (2005-05-12)
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