Women's Health Weekly
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Breast Cancer
YB-1 expression in breast cancer may indicate chemoresistance
May 12th, 2005
Y-box binding protein 1 (YB-1) expression in breast cancer may indicate chemoresistance. According to recent research from Singapore, "The Y-box binding protein 1 regulates gene expression through transcription and translation. YB-1 has been shown to be associated with up-regulation of P-glycoprotein (Pgp), an ATP-binding transporter involved in multidrug resistance. In this study, we determined the prognostic significance of YB-1 and its relationship with Pgp in patients with breast cancer." "YB-1 and Pap expression were evaluated by immunohistochemistry in resected specimens of infiltrative ductal breast cancers from 99 patients and 57 patients...
Source: Women's Health Weekly (2005-05-12)
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