Women's Health Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Women's Health Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Breast Cancer
Research looks at why recurrence happens faster in some patients than others
May 19th, 2005
According to a paper in a recent issue of Molecular Endocrinology, "Progesterone receptors (PRs) are prognostic markers in breast cancers irrespective of the patient's progestational status. However, there are two PR isoforms, PR-A and PR-B that are equimolar in the normal breast but dysregulated in advanced disease. "Postmenopausal, tamoxifen-treated patients with estrogen receptor (ER)-positive, PR-A-rich tumors have much faster disease recurrence than patients with PR-B-rich tumors." "To study the mechanisms we engineered ER+ breast cancer cells that express each PR isoform under control of an inducible promoter," wrote B.M. Jacobsen and...
Source: Women's Health Weekly (2005-05-19)
|
