Women's Health Weekly
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Cancer Genetics
BARD1 implicated as potential tumor suppressor
May 19th, 2005
BARD1 was implicated as a potential tumor suppressor. "The BARD1 gene is mutated in a subset of breast and ovarian cancers, implicating BARD1 as a potential tumor suppressor. BARD1 gains a ubiquitin E3 ligase activity when heterodimerized with BRCA1, but the only known BRCA1-independent BARD1 function is a p53-dependent proapoptotic activity stimulated by nuclear export to the cytoplasm," investigators in Australia reported. "We described previously the nuclear-cytoplasmic shuttling of BARD1, and in this study, we identify the transport sequences that target BARD1 to the nucleus and show that they are essential for BARD1 regulation of the cell cycle....
Source: Women's Health Weekly (2005-05-19)
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