Women's Health Weekly
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Addiction Medicine
Prenatal exposure to nicotine causes deficits linked to loss of nAChR function
May 19th, 2005
Prenatal exposure to nicotine causes deficits linked to loss of nicotinic acetylcholine receptor function, according to a study in mice. Karolinska Institute researchers "investigated the role played by beta 2-containing neuronal nicotinic receptors [nicotinic acetylcholine receptors (nAChRs)] in mediating nicotine's side effects in the fetus and newborn." G. Cohen and colleagues described their procedure: "Pregnant WT and mutant mice lacking the 132 nAChR subunit were implanted with osmotic minipumps that delivered either water or a controlled dose of nicotine. Subsequently, we compared the development of the sympathoadrenal system and breathing and...
Source: Women's Health Weekly (2005-05-19)
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