Women's Health Weekly
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Breast Cancer
BCRP involved in the maintenance of cellular folate homeostasis
May 26th, 2005
Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) was identified as a novel mechanism of adaptation to short-term folate deprivation. "The unique capability of BCRP/ABCG2 to export mono-, di-, and triglutamates of folates should limit cellular proliferation under conditions of folate deprivation, particularly upon BCRP overexpression. Here, we explored the mode of adaptation of BCRP-overexpressing cells to short-term folate deprivation. MCF-7/MR cells grown in high folate medium (2.3 mcM folic acid) containing mitoxantrone had 62% of their overexpressed BCRP in the plasma membrane and only 38% in the cytoplasm," scientists in Israel...
Source: Women's Health Weekly (2005-05-26)
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