Tamoxifen
Methylation rate of the ER beta gene and tamoxifen resistance inversely related
Published in Women's Health Weekly, May 26th, 2005
According to recent research published in the Journal of Molecular Medicine, "No reports have examined the association between tamoxifen resistance and the methylation of the estrogen receptor (ER) alpha and beta genes. Therefore we investigated the methylation patterns of the ER genes in the tamoxifen-resistant tumors. We used bisulfite genomic sequencing and reverse transcriptase PCR to determine the methylation patterns and mRNA expression of the two ER genes from control (n=68) and tamoxifen-resistant tissues (n=34) chosen by an age-matched sampling...
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