Women's Health Weekly
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Cancer Vaccine
Antibody construct eradicates colon and ovarian cancer tumors
May 26th, 2005
A single-chain Ep-CAM-/CD3-bispecific antibody construct eradicated tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice. "Bispecific T-cell engager (BiTE) are a class of bispecific single-chain antibodies that can very effectively redirect cytotoxic T cells for killing of tumor target cells. Here, we have assessed the in vivo efficacy of one representative, called bscEp-CAMxCD3, with specificity for tumors overexpressing epithelial cell adhesion molecule (Ep-CAM) in human xenograft models. Cells of the human colon carcinoma line SW480 were mixed at a 1:1 ratio with unstimulated human peripheral mononuclear cells, s.c....
Source: Women's Health Weekly (2005-05-26)
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