Ovarian Cancer

Blocking COX-1 slows tumor growth in mice

Published in Women's Health Weekly, May 26th, 2005

Blocking the COX-1 enzyme - not COX-2 - might lead to a way to prevent and treat the most common and fatal form of ovarian cancer, researchers at Vanderbilt University Medical Center report.

"The finding that COX-1 inhibition slowed the growth of epithelial ovarian tumors in a mouse model of the disease is surprising," said Sudhansu K. Dey, PhD, senior author of the paper and director of the Division of Reproductive and Developmental Biology in the Vanderbilt Department of Pediatrics.

Previous studies have linked high levels of another cyclooxygenase enzyme, COX-2, to colorectal and other cancers.

"But this is the exception," said...

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Source: Women's Health Weekly (2005-05-26)

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