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Impact of misclassification of IVF in twinning studies investigated

Scientists in the United States and Sweden conducted a study "to determine whether failure to adequately adjust for a reported 40% misclassification of use of in vitro fertilization (IVF) as reported in a Swedish study could have led to a false finding that folic acid increases dizygotic twinning. In 1995-9, Swedish women who used IVF had almost 20 times the chance of having twins than women who did not use IVF (rate ratio 19.7, 95% confidence interval 18.7 to 20.6). In the absence of true effect of folic acid, the use of a 40%...

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