Breast Cancer
AMAP1 expression provides targets to inhibit breast cancer invasive activities
Published in Women's Health Weekly, June 2nd, 2005
According to a recently published study in the EMBO Journal, "Identification of the molecular machinery employed in cancer invasion, but not in normal adult cells, will greatly contribute to cancer therapeutics.
"Here we found that an ArfGAP, AMAP1/PAG2, is expressed at high levels in highly invasive breast cancer cells, but at very low levels in noninvasive breast cancer cells and normal mammary epithelial cells."
"siRNA-mediated silencing of AMAP1 effectively blocked the invasive activities. AMAP1 expression in human breast primary tumors also...
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