Women's Health Weekly
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Breast Cancer
ERBB2 variant Ile654Val associated with increased familial breast cancer risk
June 2nd, 2005
The ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk. According to published research from Germany, "Overexpression of the proto-oncogene ERBB2 (HER2/NEU) has been observed in 20-30% of breast cancers involving poor prognosis. Genetic alterations within ERBB2 have been shown to induce carcinogenesis and metastasis. "We investigated eight annotated single nucleotide polymorphisms for occurrence in familial breast cancer samples. The confirmed variants Ile654Val, Ile655Val and Ala1170Pro were analyzed in subsequent epidemiological studies on familial breast cancer risk." "While Ala1170Pro resides...
Source: Women's Health Weekly (2005-06-02)
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