Women's Health Weekly
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Breast Cancer
HIV Tat targeted into mitochondria of breast cancer cells
June 2nd, 2005
HIV Tat is targeted into the mitochondria of breast cancer cells. According to a study from the United States, "The protein transduction domain (PTD) from the HIV-1 TAT protein has been widely utilized to deliver biologically active macromolecules, including full-length proteins, into a variety of cell types in vitro and in vivo. "Without additional targeting signals, the intracellular localization of the proteins delivered in this fashion appears to be cytoplasmic, nuclear or, as recently reported, endosomal." "In this study," reported I.N. Shokolenko and coworkers at the University of Southern Alabama in Mobile, "we show that...
Source: Women's Health Weekly (2005-06-02)
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