Women's Health Weekly
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Breast Cancer
Interleukin-10 promoter polymorphism associated with lower breast cancer risk
June 2nd, 2005
Interleukin-10 (TCATA) promoter polymorphism was associated with decreased breast cancer risk. According to a study from Austria, "Interleukin-10 (IL-10) is an immunosuppressive cytokine which may facilitate development of cancer by supporting tumor escape from the immune response. A (TCATA) haplotype formed by polymorphisms at positions -3575, -2763, -1082, -819 and -592 in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the -592C > A polymorphism." "Aim of the present study was to analyze the role of the IL-10 (TCATA) haplotype for breast cancer. We...
Source: Women's Health Weekly (2005-06-02)
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