Women's Health Weekly
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Breast Cancer
MAPH assesses genomic imbalances in malignant tissues
June 2nd, 2005
Multiplex Amplifiable Probe Hybridization may be used to assess genomic imbalances in malignant tissues. According to a study from England, "Loss of the chromosomal material at 16q22.1 is one of the most frequent genetic aberrations found in both lobular and low-grade nonlobular invasive carcinoma of the breast, indicating the presence of a tumor suppressor gene (TSG) at this region in these tumors. "However, the TSG (s) at the 16q22.1 in the more frequent nonlobular carcinomas is still unknown. Multiplex Amplifiable Probe Hybridisation (MAPH) is a simple, accurate and a high-resolution technique that provides an alternative approach to DNA...
Source: Women's Health Weekly (2005-06-02)
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