Women's Health Weekly
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Breast Cancer
NF kappa B activation identifies high-risk subset of ER-dependent cancers
June 2nd, 2005
Nuclear factor-kappa B activation appears to be a marker for a high-risk subset of estrogen receptor-positive breast cancers. "Activation of nuclear factor-kappa B (NF kappa B) has been linked to the development of hormone-independent, estrogen receptor (ER) negative human breast cancers," wrote Y.M. Zhou and colleagues, Buck Institute Age Research. "To explore the possibility that activated NF kappa B marks a subset of clinically more aggressive ER-positive breast cancers, NF kappa B DNA-binding was measured in ER-positive breast cancer cell lines and primary breast cancer extracts by electrophoretic mobility shift assay and enzyme-linked...
Source: Women's Health Weekly (2005-06-02)
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