Women's Health Weekly
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Breast Cancer
Refeeding after chronic dietary energy restriction reverses anticancer effect
June 2nd, 2005
Refeeding after chronic dietary energy restriction reverses the anticancer effect of dietary energy restriction. "Dietary energy restriction (DER) is a potent inhibitor of mammary carcinogenesis, but the responsible mechanisms are not fully understood. In a number of model systems, DER is associated with a decrease in circulating levels of IGF-1. "Moreover, we have recently reported that protection against cancer is lost, and plasma IGF-1 levels are restored to control values when animals are re-fed, i.e, energy repleted (DER-REP)," scientists writing in the journal Molecular Carcinogenesis report. "Accordingly, an...
Source: Women's Health Weekly (2005-06-02)
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