Women's Health Weekly
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Breast Cancer
SPARC sways survival and tumor progression in breast cancer patients
June 2nd, 2005
SPARC sways survival and tumor progression in breast cancer patients. "SPARC (secreted protein acidic and rich in cystein), also known as osteonectin and BM40, is a 32 kDa secreted glycoprotein that interacts with extracellular matrix (ECM) proteins to promote adhesion of cells from the matrix, thereby inducing a biological state conducive to cell migration. SPARC is also thought to play an important role in tissue remodeling, angiogenesis, embryonic development and tumorigenesis," according to scientists in Wales. "The current study set out to examine both the transcript levels of SPARC and the presence of the molecule in breast cancer tissue and to...
Source: Women's Health Weekly (2005-06-02)
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