Women's Health Weekly
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Breast Cancer
Valproic acid/RA/Aza-dC restores silenced RAR beta 2 expression in breast cancer
June 2nd, 2005
Valproic acid plus retinoic acid and Aza-dC restores silenced RAR beta 2 expression in breast cancer cells. "Epigenetic silencing of tumor suppressor genes has been established as an important process of carcinogenesis. The retinoic acid (RA) receptor 2 (RAR beta 2) gene is one such tumor suppressor gene often silenced during carcinogenesis. "The combined use of histone deacetylase and DNA methyltransferase inhibitors has been shown to reverse the epigenetic silencing of numerous growth regulatory genes," researchers in the United States report. "Valproic acid (VPA), which has long been used in the treatment of epilepsy, was shown...
Source: Women's Health Weekly (2005-06-02)
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