Women's Health Weekly
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Breast Cancer
NCOA3 polymorphisms associated with protective effect against breast cancer
June 9th, 2005
NCOA3 polymorphisms are associated with a protective effect against breast cancer. According to a recently published study from Germany, "The nuclear receptor, coactivator 3 (NCOA3, also known as AIB1), is a coactivator of nuclear receptors like the estrogen receptor. "NCOA3 is overexpressed in similar to 60% of primary human breast tumors, and high levels of NCOA3 expression are associated with tamoxifen resistance and worse survival rate. In contrast, NCOA3 deficiency suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. "Here, we analyzed the influence of NCOA3 coding single nucleotide polymorphisms on...
Source: Women's Health Weekly (2005-06-09)
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