Women's Health Weekly
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Cancer Therapy
Pituitary tumor-transforming gene depletion eradicates tumor growth
June 9th, 2005
Pituitary tumor-transforming gene depletion eradicates tumor growth. "The proto-oncogene pituitary tumor-transforming gene (PTTG) is described as abundantly overexpressed in a variety of neoplasms with impact on neovascularization and tumor invasiveness. Based on these findings, we raised the question as to whether PTTG is a target for an antitumor therapy," investigators in Germany report. "To investigate the impact of PTTG depletion on the human cervical cancer cell line HELA-S3, we used antisense-oligodeoxynucleotides (antisense-ODNs) and subjected them to in vitro transfection experiments. The PTTG mRNA level was determined by reverse...
Source: Women's Health Weekly (2005-06-09)
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