Women's Health Weekly
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Breast Cancer
HER-2 overexpression inversely correlates with ER/PR expression in breast cancer
June 16th, 2005
HER-2 overexpression inversely correlates with estrogen and progesterone receptor expression in invasive breast cancer. "We studied the inverse relationship between HER-2 and estrogen (ER) and progesterone (PR) receptors using HER-2 testing and correlated HER-2 status with histologic features in 3,655 unselected invasive breast carcinomas. "Immunohistochemical analysis for ER, PR, HER-2, and fluorescence in situ hybridization for HER-2 was performed," researchers in the United States report. "ER and PR expression were decreased significantly in HER-2+ tumors compared with HER-2-tumors (ER, 49.1 vs. 78.17%; PR, 24.3 vs. 53.13%)....
Source: Women's Health Weekly (2005-06-16)
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