Women's Health Weekly
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Breast Cancer
VEGF-D has direct and indirect effects on breast carcinoma cell proliferation
June 23rd, 2005
VEGF-D has direct and indirect effects on breast carcinoma cell proliferation. According to recent research from the United States, "vascular endothelial growth factor-D (VEGF-D) binds and activates vascular endothelial growth factor receptor-2 (VEGFR-2), which signals for angiogenesis, and VEGFR-3, which signals for lymphangiogenesis. Besides endothelial cells, VEGFR-2 has been detected on malignant cells, including human breast carcinoma cells." "It was examined if ectopic expression of human VEGF-D affected growth of breast carcinoma cell lines in vitro and in vivo. VEGF-D overexpressing clonal MCF-7 and MDA-MB-231 cell lines displayed increased...
Source: Women's Health Weekly (2005-06-23)
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