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Animal Studies

Altered leptin physiology linked to decline in reproduction function

According to a study in a recent issue of Reproduction Nutrition Development, "Mice possessing the lethal yellow mutation (C57BL/6J A(y)/a) become obese and develop hyperleptinemia and leptin resistance as they age. To determine the relationship between altered leptin physiology and reproductive function in these mice, we compared body weight (BW), serum leptin concentration, ovulation rate, and in vitro blastocyst development among 120-and 180-d-old lethal yellow and black non-mutant (a/a) mice."

J.D. Brannian and associates at the University of South Dakota explained,...

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