Women's Health Weekly
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Breast Cancer
Cancer cells secrete growth factors to lure stem cells
June 30th, 2005
Like a siren song, breast cancer cells secrete growth factors to attract stem cells, then use those cells - which normally promote healing - to help the growing tumor survive, researchers have found. In the laboratory, the researchers have documented secretion of fibroblast growth factor type 2 (FGF2) and vascular endothelial growth factor (VEGF) by breast cancer cells, seen these factors bind to receptors on stem cells, then watched stem cells migrate toward the cancer. When they took the growth factors away, the deadly migration decreased. "These stem cells are there to make normal tissue; they make fat, cartilage, bone," explains Adam Perry,...
Source: Women's Health Weekly (2005-06-30)
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