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Women's Health Weekly

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Cardiovascular Disease



Cardiac PKC-ERK1/2 signaling modules differ between sexes in size, distribution



June 30th, 2005

Cardiac protein kinase C-extracellular regulated 1/2 signaling modules differ in both size and distribution between women and men, physiologists report.

"Cardiovascular morbidity and mortality increase significantly with advancing age, with proportionally higher rates occurring in aged women when compared to aged men. The signaling alterations responsible for age-related reductions in ischemic stress reserves, particularly in aged women, are poorly understood," wrote J.C. Hunter and colleagues, Pennsylvania State University.

Hunter's group conducted a study in rats to "determine whether alterations in the cellular location and formation of specific...


Source: Women's Health Weekly (2005-06-30)

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