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Addiction Medicine

Developing lung studied, expression and modulation of lynx1 clarified

Published in Women's Health Weekly, June 30th, 2005

A study from the United States has reported on the expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure.

"The expression of nicotinic acetylcholine receptors (nAChR) in fetal lung suggests maternal smoking during pregnancy effects newborn lung structure and function by the direct interaction of nicotine with nAChR in the developing lung. The recent identification of the lynx1 nAChR modulator protein in nicotinic neurons in the brain suggests that lynx1 may be similarly expressed in the lung," wrote H.S. Sekhon and colleagues, Oregon Health & Science University.

"To study this, cDNAs encoding lynx1 were cloned from...

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