Women's Health Weekly
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Breast Cancer
DNA vaccination/BAT combo protects against incipient carcinomas
July 7th, 2005
DNA vaccination/BAT combo protects against incipient carcinomas. "Over the course of 33 weeks from birth, the mammary glands of virgin female BALB/c mice transgenic for the transforming rat Her-2/neu oncogene progress from atypical hyperplasia to invasive carcinoma. By week 12, all their mammary glands display many foci of in situ carcinoma," scientists in Italy reported recently in Vaccine. "DNA vaccination at weeks 12 and 14 through in vivo electroporation of a plasmid encoding for the extracellular and transmembrane domain of the protein product of rat Her-2/neu oncogene kept 33% of mice tumor-free until week 35, when the experiment ended....
Source: Women's Health Weekly (2005-07-07)
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